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In addition, ferroptosis is instrumental in the process of endothelial dysfunction caused by hyperglycemia[87]

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The shRNA-mediated inhibition of GOT1 expression enhances cancer cell sensitivity to doxorubicin by causing doxorubicin-induced ROS generation ( The enzymatic activity of GPT2 is pivotal to the anchorage-independent growth of KRAS-transformed colon cancer cells ( Recent studies show that elevated ratios of aspartate to alanine transaminases (AST/ALT or GOT/GPT) correlate with a poor prognosis in bladder ( 2.3.4 Glutamine synthetase Glutamine can be synthesized de novo from glutamate via glutamine synthase (GS)